27^th Euro-Global Neurologists Meeting

Cognitive decline is characteristic of various pathological conditions including traumatic brain injury (TBI) and can accompany normal aging. Technologies of neurorehabilitation exploiting the structural-functional plasticity of the brain

could promote the forming of new connections to compensate the cognitive deficit. Methods of cognitive rehabilitation include techniques of mental and physical training and different regimens of stimulation therapy such as transcranial magnetic and electrical stimulation, and low-intensity stimulation by sensory stimuli, positive effects of which were shown in many studies.

However, taking into account that in aging and pathology potential of neuroplasticity is reduced, the efficacy of any methods of neurorehabilitation can be objectively restricted. Besides, in the stimulation therapy, optical, audio and other signals with a regular, periodic temporal structure are usually applied. The periodic rhythms can provide some improvement of the cortical

activity in the particular range of EEG. But they cannot restore complex fractal dynamics of the brain's activity typical of a healthy person and improve the cognitive ability of the patient. We suppose that the fractal stimulation by complex-structured optical signals and sound tones will promote activating the structural-functional plasticity and improve cognitive functions in pathological conditions associated with the cognitive decline. Evoked changes in the cortical activity can ensure the impact of stimulation on cognitive functions. Because the fractal stimulation is supposed to increase the potential of neuroplasticity, during the period of enhanced plasticity (against the backdrop of a course of stimulation therapy) an increase in the efficiency of different others neurorehabilitation measures should be expected.